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For instance, studies in germ-free or antibiotic-treated mouse and rhesus monkey models have demonstrated reduced levels of BBB tight junction proteins (e.g., claudin-5, occludin) and increased BBB permeability

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60 DieckS.Sanmart-VilaL.LangnaeseK.RichterK.KindlerS.SoykeA.et al (1998)

Understanding these mechanisms explains why certain peptides show such compelling neuropathy research and why a multi-peptide approach often makes more sense than targeting a single pathway